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pentobarbital will minimize the level or result of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Strong or average CYP3A4 inducers noticeably cut down guanfacine plasma concentrations and elimination 50 percent-existence.Just after stopping a CYP3A4 inducer, as the effects in the inducer decrea